mouse DNAJC2 shRNA silencing AAV

Name
AAV-m-DNAJC2-shRNA

Cat No
shAAV-257306

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Dnajc2.

shAAV-257306

AAV-m-DNAJC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dnajc2 (DnaJ heat shock protein family (Hsp40) member C2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AU020218; MIDA1; Zrf1; Zrf2

Description (Vector)

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Gene ID

22791

Gene Name (Vector)

DnaJ heat shock protein family (Hsp40) member C2

Gene Symbol

Dnajc2

ORF Size (aa)

1866

ORF Size (bp)

1866 bp

RefSeq ID

NM_009584

RefSeq Synonyms

NM_009584, BC052027,

Species

mouse

UniGene ID

Mm.266312

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.