mouse DMRT1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Dmrt1.
shAAV-257256
AAV-m-DMRT1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Dmrt1 (doublesex and mab-3 related transcription factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Gene ID
50796
Gene Name (Vector)
doublesex and mab-3 related transcription factor 1
Gene Symbol
Dmrt1
ORF Size (aa)
1125
RefSeq ID
NM_015826
RefSeq Synonyms
NM_015826, BC125474,
Species
mouse
UniGene ID
Mm.391208
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.