mouse DDR2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ddr2.
shAAV-256911
AAV-m-DDR2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ddr2 (discoidin domain receptor family, member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW495251; Ntrkr3; tyro10
Description (Vector)
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Gene ID
18214
Gene Name (Vector)
discoidin domain receptor family, member 2
Gene Symbol
Ddr2
ORF Size (aa)
2565
ORF Size (bp)
2565 bp
RefSeq ID
NM_022563
RefSeq Synonyms
NM_022563, BC138827, BC138826,
Species
mouse
UniGene ID
Mm.477411
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.