human GABRB3 Over-expression AAV

Name
AAV-h-GABRB3

Cat No
AAV-209520

Availability
4-5 weeks

This is an AAV expressing Human GABRB3.

AAV-209520

AAV-h-GABRB3

Ready-to-use AAV expressing Human GABRB3 (gamma-aminobutyric acid type A receptor beta3 subunit). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ECA5; EIEE43

Description (Vector)

GABRB3 encodes a member of the ligand-gated ionic channel family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. GABRB3 is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene ID

2562

Gene Name (Vector)

gamma-aminobutyric acid type A receptor beta3 subunit

Gene Symbol

GABRB3

HGNC ID

HGNC:4083

ORF Size (aa)

1422

ORF Size (bp)

1422 bp

RefSeq ID

NM_000814

RefSeq Synonyms

NM_021912, NM_001278631, NM_001191321, NM_001191320, NM_000814, BC010641,

Species

human

UniGene ID

Hs.657298

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.