mouse RORA shRNA silencing AAV

Name
AAV-m-RORA-shRNA

Cat No
shAAV-256623

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Rora.

shAAV-256623

AAV-m-RORA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Rora (RAR-related orphan receptor alpha). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2; ROR3; sg; staggerer; tmgc26

Description (Vector)

Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.

Gene ID

19883

Gene Name (Vector)

RAR-related orphan receptor alpha

Gene Symbol

Rora

ORF Size (aa)

1383

ORF Size (bp)

1383 bp

RefSeq ID

NM_013646

RefSeq Synonyms

NM_013646, NM_001289917, NM_001289916, BC003757,

Species

mouse

UniGene ID

Mm.427266

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.