mouse CDC14B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cdc14b.
shAAV-255073
AAV-m-CDC14B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cdc14b (CDC14 cell division cycle 14B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810432N10Rik; A530086E13Rik; AA472821; Cdc14B1; CDC14B3
Description (Vector)
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Gene ID
218294
Gene Name (Vector)
CDC14 cell division cycle 14B
Gene Symbol
Cdc14b
ORF Size (aa)
1458
ORF Size (bp)
1458 bp
RefSeq ID
NM_172587
RefSeq Synonyms
NM_172587, NM_001122989, BC057357, BC049794,
Species
mouse
UniGene ID
Mm.25335
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.