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mouse CASP8AP2 shRNA silencing AAV

Name 
AAV-m-CASP8AP2-shRNA
Cat No 
shAAV-254564
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Casp8ap2.

shAAV-254564
AAV-m-CASP8AP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Casp8ap2 (caspase 8 associated protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D4Ertd659e; FLASH
Description (Vector)
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Gene ID
26885
Gene Name (Vector)
caspase 8 associated protein 2
Gene Symbol
Casp8ap2
ORF Size (aa)
5889
ORF Size (bp)
5889 bp
RefSeq ID
NM_011997
RefSeq Synonyms
NM_011997, NM_001122978, BC138041, BC138022,
Species
mouse
UniGene ID
Mm.22279

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.