mouse CAMK2B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Camk2b.
shAAV-254441
AAV-m-CAMK2B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Camk2b (calcium/calmodulin-dependent protein kinase II, beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CaMKII
Description (Vector)
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Gene ID
12323
Gene Name (Vector)
calcium/calmodulin-dependent protein kinase II, beta
Gene Symbol
Camk2b
ORF Size (aa)
1638
ORF Size (bp)
1638 bp
RefSeq ID
NM_007595
RefSeq Synonyms
NM_007595, NM_001174054, NM_001174053, BC080273,
Species
mouse
UniGene ID
Mm.439733
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.