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mouse BCOR shRNA silencing AAV

Name 
AAV-m-BCOR-shRNA
Cat No 
shAAV-253918
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Bcor.

shAAV-253918
AAV-m-BCOR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Bcor (BCL6 interacting corepressor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2900008C10Rik; 5830466J11Rik; 8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575
Description (Vector)
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
Gene ID
71458
Gene Name (Vector)
BCL6 interacting corepressor
Gene Symbol
Bcor
ORF Size (aa)
5178
ORF Size (bp)
5178 bp
RefSeq ID
NM_029510
RefSeq Synonyms
NM_175046, NM_175045, NM_175044, NM_029510, NM_001168321, BC058656,
Species
mouse
UniGene ID
Mm.196328

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.