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human BCOR shRNA silencing Adenovirus

Name 
Ad-h-BCOR-shRNA
Cat No 
shADV-202072
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human BCOR.

shADV-202072
Ad-h-BCOR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human BCOR (BCL6 corepressor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ANOP2; BCL-6 corepressor; BCL-6 interacting corepressor; BCoR; MAA2; MCOPS2
Description (eCommerce)
The BCL6 co-repressor (BCOR) was identified in a two-hybrid screen for factors that interact with the POZ domain of BCL6, a transcriptional repressor important to the immune response and B-cell development. BCOR also interacts with class I and II histone deacetylases and has recently been identified in a complexes with polycomb group proteins, RING1, RYBP, SNSC1, and RNF2, and the ubiquitin E3 ligase SKP1, and JHDM1B. Defects in BCOR are associated with oculo-facio-cardio-dental (OFCD) syndrome, a rare X-linked dominant disease that is fatal in males.
Description (Vector)
BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
Gene ID
54880
Gene Name (eCommerce)
BCL6 corepressor
Gene Name (Vector)
BCL6 corepressor
Gene Symbol
BCOR
HGNC ID
HGNC:20893
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5112
ORF Size (bp)
5112 bp
Protein Name (eCommerce)
BCL-6 corepressor
RefSeq ID
NM_017745
RefSeq Synonyms
NM_017745, NM_001123385, NM_001123384, NM_001123383, BC114220,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Histone Modification,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,transcription_translation
Species
human
Target Sentence
The BCL6 co-repressor (BCOR) was identified in a two-hybrid screen for factors that interact with the POZ domain of BCL6, a transcriptional repressor important to the immune response and B-cell development. BCOR also interacts with class I and II histone deacetylases and has recently been identified in a complexes with polycomb group proteins, RING1, RYBP, SNSC1, and RNF2, and the ubiquitin E3 ligase SKP1, and JHDM1B. Defects in BCOR are associated with oculo-facio-cardio-dental (OFCD) syndrome, a rare X-linked dominant disease that is fatal in males.
UniGene ID
Hs.659681
UniProt ID (eCommerce)
Q6W2J9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.