mouse AGAP2 shRNA silencing AAV

Name 
AAV-m-AGAP2-shRNA
Cat No 
shAAV-252218
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Agap2.

shAAV-252218
AAV-m-AGAP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Agap2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AGAP-2; Centg1; cnt-g1; mKIAA0167; PIKE
Description (Vector)
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Gene ID
216439
Gene Name (Vector)
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene Symbol
Agap2
ORF Size (aa)
3561
ORF Size (bp)
3561 bp
RefSeq ID
NM_001033263
RefSeq Synonyms
NM_001301014, NM_001033263, BC156808,
Species
mouse
UniGene ID
Mm.336761

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.