human AGAP2 shRNA silencing Adenovirus

Name 
Ad-h-AGAP2-shRNA
Cat No 
shADV-200547
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human AGAP2.

shADV-200547
Ad-h-AGAP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AGAP-2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; Centaurin-gamma-1; CENTG1; cnt-g1; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; phosphatidylinositol 3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKE
Description (eCommerce)
Phosphatidylinositol 3-kinase enhancer (PIKE) belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion [taken from NCBI Entrez Gene (Gene ID: 116986)].
Description (Vector)
AGAP2 belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
116986
Gene Name (eCommerce)
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene Name (Vector)
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene Symbol
AGAP2
HGNC ID
HGNC:16921
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2511
ORF Size (bp)
2511 bp
Protein Name (eCommerce)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
RefSeq ID
NM_014770
RefSeq Synonyms
NM_014770, NM_001122772, BC028020,
Research Areas
Apoptosis,Axon Guidance,Cancer,Mitochondrion,Neurobiology,Neurodevelopment,Prolactin Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Phosphatidylinositol 3-kinase enhancer (PIKE) belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion [taken from NCBI Entrez Gene (Gene ID: 116986)].
UniGene ID
Hs.632854
UniProt ID (eCommerce)
Q99490

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.