mouse NUMBL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Numbl.
shAAV-251573
AAV-m-NUMBL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Numbl (numb-like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
nbl
Description (Vector)
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Gene ID
18223
Gene Name (Vector)
numb-like
Gene Symbol
Numbl
ORF Size (aa)
1815
ORF Size (bp)
1815 bp
RefSeq ID
NM_010950
RefSeq Synonyms
NM_010950, BC098097, BC068116,
Species
mouse
UniGene ID
Mm.458153
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.