human BAIAP2L1 shRNA silencing AAV

Name 
AAV-h-BAIAP2L1-shRNA
Cat No 
shAAV-232097
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BAIAP2L1.

shAAV-232097
AAV-h-BAIAP2L1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BAIAP2L1 (BAI1 associated protein 2 like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BAI1-associated protein 2-like protein 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate; IRTKS
Description (eCommerce)
BAIAP2L1 may function as adapter protein. It is Involved in the formation of clusters of actin bundle and plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHR4].
Description (Vector)
BAIAP2L1 encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
Gene ID
55971
Gene Name (eCommerce)
BAI1 associated protein 2 like 1
Gene Name (Vector)
BAI1 associated protein 2 like 1
Gene Symbol
BAIAP2L1
HGNC ID
HGNC:21649
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1536
ORF Size (bp)
1536 bp
Protein Name (eCommerce)
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
RefSeq ID
NM_018842
RefSeq Synonyms
NM_018842, BC013888,
Research Areas
Cytoskeleton,EGFR Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
BAIAP2L1 may function as adapter protein. It is Involved in the formation of clusters of actin bundle and plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UHR4].
UniGene ID
Hs.656063
UniProt ID (eCommerce)
Q9UHR4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.