human NOX4 shRNA silencing AAV

Name 
AAV-h-NOX4-shRNA
Cat No 
shAAV-230059
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NOX4.

shAAV-230059
AAV-h-NOX4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOX4 (NADPH oxidase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
KOX; KOX-1; RENOX
Description (Vector)
NOX4 encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
Gene ID
50507
Gene Name (Vector)
NADPH oxidase 4
Gene Symbol
NOX4
HGNC ID
HGNC:7891
ORF Size (aa)
1737
ORF Size (bp)
1737 bp
RefSeq ID
NM_016931
RefSeq Synonyms
NM_016931, NM_001300995, NM_001291929, NM_001291927, NM_001291926, NM_001143837, NM_001143836, BC040105,
Species
human
UniGene ID
Hs.371036

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.