human TNFSF12 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TNFSF12.
shAAV-229846
AAV-h-TNFSF12-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TNFSF12 (tumor necrosis factor superfamily member 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APO3L; DR3LG; TNLG4A; TWEAK
Description (Vector)
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Gene ID
8742
Gene Name (Vector)
tumor necrosis factor superfamily member 12
Gene Symbol
TNFSF12
HGNC ID
HGNC:11927
ORF Size (aa)
750
RefSeq ID
NM_003809
RefSeq Synonyms
NM_003809, BC104420, BC071837, BC019047,
Species
human
UniGene ID
Hs.
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.