human EPC1 shRNA silencing AAV

Name 
AAV-h-EPC1-shRNA
Cat No 
shAAV-229133
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EPC1.

shAAV-229133
AAV-h-EPC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPC1 (enhancer of polycomb homolog 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
enhancer of polycomb homolog 1; Epl1
Description (eCommerce)
Enhancer of polycomb homolog 1 (EPC1) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2F5].
Gene ID
80314
Gene Name (eCommerce)
enhancer of polycomb homolog 1
Gene Name (Vector)
enhancer of polycomb homolog 1
Gene Symbol
EPC1
HGNC ID
HGNC:19876
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2442
ORF Size (bp)
2442 bp
Protein Name (eCommerce)
Enhancer of polycomb homolog 1
RefSeq ID
NM_025209
RefSeq Synonyms
NM_025209, NM_001282391, NM_001272019, NM_001272004, BC036529,
Research Areas
Chromatin Remodeling,Complexome,Epigenetic Regulation of Gene Expression,Gene Expression,Histone Modification,Polycomb Proteins,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Enhancer of polycomb homolog 1 (EPC1) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2F5].
UniGene ID
Hs.167805
UniProt ID (eCommerce)
Q9H2F5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.