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human ZMYM2 shRNA silencing AAV

Name 
AAV-h-ZMYM2-shRNA
Cat No 
shAAV-228284
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ZMYM2.

shAAV-228284
AAV-h-ZMYM2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ZMYM2 (zinc finger MYM-type containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
77
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FIM; fused in myeloproliferative disorders protein; MYM; RAMP; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; SCLL; zinc finger MYM-type protein 2; zinc finger protein 198; zinc finger, MYM-type 2; ZNF198
Description (eCommerce)
ZNF198 contains nine MYM-type zinc fingers. The N-terminal half of the ZNF198 gene has been identified as a gene fused to the cytoplasmic domain of the fibroblast growth factor receptor (FGFR1) gene as a result of a t(8;13) (p11;q11-12) chromosomal rearrangement. The t(8;13) chromosomal translocation is associated with myeloproliferative diseases such as stem cell leukemia lymphoma syndrome (SCLL). Studies of the normal function of ZNF198 have revealed that it associates with HHR6 and RAD18 and may be involved in the repair of DNA. ZNF198 has also been found to associate with the BHC110 subunit of a histone-deacetylase containing corepressor complex and may have an additional function in transcriptional repression.
Description (Vector)
ZMYM2 is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene.
Gene ID
7750
Gene Name (eCommerce)
zinc finger MYM-type containing 2
Gene Name (Vector)
zinc finger MYM-type containing 2
Gene Symbol
ZMYM2
HGNC ID
HGNC:12989
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4134
ORF Size (bp)
4134 bp
Protein Name (eCommerce)
Zinc finger MYM-type protein 2
RefSeq ID
NM_003453
RefSeq Synonyms
NM_197968, NM_003453, NM_001190965, NM_001190964, BC036372,
Research Areas
FGF Signaling,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
ZNF198 contains nine MYM-type zinc fingers. The N-terminal half of the ZNF198 gene has been identified as a gene fused to the cytoplasmic domain of the fibroblast growth factor receptor (FGFR1) gene as a result of a t(8;13) (p11;q11-12) chromosomal rearrangement. The t(8;13) chromosomal translocation is associated with myeloproliferative diseases such as stem cell leukemia lymphoma syndrome (SCLL). Studies of the normal function of ZNF198 have revealed that it associates with HHR6 and RAD18 and may be involved in the repair of DNA. ZNF198 has also been found to associate with the BHC110 subunit of a histone-deacetylase containing corepressor complex and may have an additional function in transcriptional repression.
UniGene ID
Hs.644041
UniProt ID (eCommerce)
Q9UBW7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.