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human ZC3H8 shRNA silencing AAV

Name 
AAV-h-ZC3H8-shRNA
Cat No 
shAAV-228104
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ZC3H8.

shAAV-228104
AAV-h-ZC3H8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ZC3H8 (zinc finger CCCH-type containing 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Fliz1; ZC3HDC8; zinc finger CCCH domain-containing protein 8; zinc finger CCCH-type domain containing 8
Description (eCommerce)
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].
Gene ID
84524
Gene Name (eCommerce)
zinc finger CCCH-type containing 8
Gene Name (Vector)
zinc finger CCCH-type containing 8
Gene Symbol
ZC3H8
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
894
ORF Size (bp)
894 bp
Protein Name (eCommerce)
Zinc finger CCCH domain-containing protein 8
RefSeq ID
NM_032494
RefSeq Synonyms
NM_032494, BC032001,
Research Areas
Apoptosis,Immunology,RNA Binding,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,transcription_translation
Species
human
Target Sentence
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity). ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8N5P1].
UniGene ID
Hs.418416
UniProt ID (eCommerce)
Q8N5P1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.