human YTHDF1 shRNA silencing AAV

Name 
AAV-h-YTHDF1-shRNA
Cat No 
shAAV-227998
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human YTHDF1.

shAAV-227998
AAV-h-YTHDF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human YTHDF1 (YTH N6-methyladenosine RNA binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C20orf21; DACA-1; dermatomyositis associated with cancer putative autoantigen 1; YTH domain family 1; YTH domain family protein 1; YTH domain family, member 1; YTH domain-containing family protein 1; YTH N(6)-methyladenosine RNA binding protein 1
Description (eCommerce)
YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation.
Gene ID
54915
Gene Name (eCommerce)
YTH N6-methyladenosine RNA binding protein 1
Gene Name (Vector)
YTH N6-methyladenosine RNA binding protein 1
Gene Symbol
YTHDF1
HGNC ID
HGNC:15867
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1680
ORF Size (bp)
1680 bp
Protein Name (eCommerce)
YTH domain-containing family protein 1
RefSeq ID
NM_017798
RefSeq Synonyms
NM_017798, BC050284,
Research Areas
RNA Binding
Research Areas (Faceted)
genetics
Species
human
Target Sentence
YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation.
UniGene ID
Hs.11747
UniProt ID (eCommerce)
Q9BYJ9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.