human XYLT2 shRNA silencing AAV

Name
AAV-h-XYLT2-shRNA

Cat No
shAAV-227943

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human XYLT2.

shAAV-227943

AAV-h-XYLT2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human XYLT2 (xylosyltransferase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PXYLT2; SOS; XT-II; XT2; xylT-II

Description (Vector)

XYLT2 is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis.

Gene ID

64132

Gene Name (Vector)

xylosyltransferase 2

Gene Symbol

XYLT2

HGNC ID

HGNC:15517

ORF Size (aa)

2598

ORF Size (bp)

2598 bp

RefSeq ID

NM_022167

RefSeq Synonyms

NM_022167, BC156444, BC052262,

Species

human

UniGene ID

Hs.463416

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.