human WWOX shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WWOX.
shAAV-227857
AAV-h-WWOX-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WWOX (WW domain containing oxidoreductase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D16S432E; EIEE28; FOR; FRA16D; fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SCAR12; SDR41C1; short chain dehydrogenase/reductase family 41C member 1; WOX1; WW domain-containing oxidoreductase; WW domain-containing protein WWOX
Description (eCommerce)
WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZC7].
Description (Vector)
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Gene ID
51741
Gene Name (eCommerce)
WW domain containing oxidoreductase
Gene Name (Vector)
WW domain containing oxidoreductase
Gene Symbol
WWOX
HGNC ID
HGNC:12799
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
705
Protein Name (eCommerce)
WW domain-containing oxidoreductase
RefSeq ID
NM_016373
RefSeq Synonyms
NM_130844, NM_130791, NM_016373, NM_001291997, BC003184,
Research Areas
Apoptosis,Cancer,Golgi Apparatus,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,metabolism,signal_transduction
Species
human
Target Sentence
WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZC7].
UniGene ID
Hs.461453
UniProt ID (eCommerce)
Q9NZC7
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.