human WAPAL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human WAPL.
shAAV-227592
AAV-h-WAPAL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human WAPL (WAPL cohesin release factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FOE; friend of EBNA2 (Epstein-Barr virus nuclear protein 2); friend of EBNA2 protein; KIAA0261; WAPAL; WAPL cohesin release factor; wings apart-like protein homolog
Description (eCommerce)
Wings apart-like protein homolog (WAPL) is a cohesin binding protein that functions to destabilize cohesin-linked sister chromatids during prophase. Human WAPL has been shown to be highly expressed in cervical cancer and when over-expressed in mouse cells, induces tumorigenesis. WAPL was isolated in a screen for proteins that interact with Epstein-Barr nuclear protein 2 (EBNA2).
Gene ID
23063
Gene Name (eCommerce)
WAPL cohesin release factor
Gene Name (Vector)
WAPL cohesin release factor
Gene Symbol
WAPL
HGNC ID
HGNC:23293
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3555
ORF Size (bp)
3555 bp
Protein Name (eCommerce)
Wings apart-like protein homolog
RefSeq ID
NM_015045
RefSeq Synonyms
NM_015045, NM_001318328, BC150269, BC140858, BC017393,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,DNA Replication
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Wings apart-like protein homolog (WAPL) is a cohesin binding protein that functions to destabilize cohesin-linked sister chromatids during prophase. Human WAPL has been shown to be highly expressed in cervical cancer and when over-expressed in mouse cells, induces tumorigenesis. WAPL was isolated in a screen for proteins that interact with Epstein-Barr nuclear protein 2 (EBNA2).
UniGene ID
Hs.714876
UniProt ID (eCommerce)
Q7Z5K2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.