human VPS24 shRNA silencing AAV

Name 
AAV-h-VPS24-shRNA
Cat No 
shAAV-227515
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CHMP3.

shAAV-227515
AAV-h-VPS24-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHMP3 (charged multivesicular body protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
25.1 protein; CGI-149; charged multivesicular body protein 3; CHMP family, member 3; chromatin-modifying protein 3; hVps24; NEDF; neuroendocrine differentiation factor; vacuolar protein sorting 24 homolog; vacuolar protein sorting-associated protein 24; VPS24
Description (eCommerce)
Charged multivesicular body protein 3 (CHMP3) is a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. CHMP3 may also co-immunoprecipitate with a member of the IFG-binding protein superfamily [taken from NCBI Entrez Gene (Gene ID: 51652)].
Description (Vector)
CHMP3 encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene.
Gene ID
51652
Gene Name (eCommerce)
charged multivesicular body protein 3
Gene Name (Vector)
charged multivesicular body protein 3
Gene Symbol
CHMP3
HGNC ID
HGNC:29865
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
669
ORF Size (bp)
669 bp
Protein Name (eCommerce)
Charged multivesicular body protein 3
RefSeq ID
NM_016079
RefSeq Synonyms
NM_016079, NM_001193517, NM_001005753, BC004419,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Host-Virus Interactions,Lysosomal Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease
Species
human
Target Sentence
Charged multivesicular body protein 3 (CHMP3) is a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. CHMP3 may also co-immunoprecipitate with a member of the IFG-binding protein superfamily [taken from NCBI Entrez Gene (Gene ID: 51652)].
UniGene ID
Hs.591582
UniProt ID (eCommerce)
Q9Y3E7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.