human VPRBP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DCAF1.
shAAV-227510
AAV-h-VPRBP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DCAF1 (DDB1 and CUL4 associated factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; protein VPRBP; RIP; serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VPRBP; vpr-interacting protein
Description (eCommerce)
VprBP (HIV-1 Vpr-binding protein) is also known as DCAF1 (Ddb1- and Cul4-associated factor 1). VprBP was initially identified as a protein that co-immunoprecipitated with the HIV protein, viral protein R; however the physiological relevance of this association remains unclear. It has recently been shown that VprBP plays an essential role in cell cycle progression, and it associates with the DDB1-CUL4 E3 ligase complex.
Gene ID
9730
Gene Name (eCommerce)
DDB1 and CUL4 associated factor 1
Gene Name (Vector)
DDB1 and CUL4 associated factor 1
Gene Symbol
DCAF1
HGNC ID
HGNC:30911
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4521
ORF Size (bp)
4521 bp
Protein Name (eCommerce)
Protein VPRBP
RefSeq ID
NM_014703
RefSeq Synonyms
NM_014703, NM_001171904, BC110371, BC022792,
Research Areas
Antigen Processing and Presentation,Cell Biology,Cell Cycle,Immunology,Kinase/Phosphatase,Transcription Factor/Regulator,Translational Control,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
VprBP (HIV-1 Vpr-binding protein) is also known as DCAF1 (Ddb1- and Cul4-associated factor 1). VprBP was initially identified as a protein that co-immunoprecipitated with the HIV protein, viral protein R; however the physiological relevance of this association remains unclear. It has recently been shown that VprBP plays an essential role in cell cycle progression, and it associates with the DDB1-CUL4 E3 ligase complex.
UniGene ID
Hs.716623
UniProt ID (eCommerce)
Q9Y4B6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.