human VPRBP Over-expression AAV

Name
AAV-h-VPRBP

Cat No
AAV-227509

Availability
4-5 weeks

This is an AAV expressing Human DCAF1.

AAV-227509

AAV-h-VPRBP

Ready-to-use AAV expressing Human DCAF1 (DDB1 and CUL4 associated factor 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; protein VPRBP; RIP; serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VPRBP; vpr-interacting protein

Description (eCommerce)

VprBP (HIV-1 Vpr-binding protein) is also known as DCAF1 (Ddb1- and Cul4-associated factor 1). VprBP was initially identified as a protein that co-immunoprecipitated with the HIV protein, viral protein R; however the physiological relevance of this association remains unclear. It has recently been shown that VprBP plays an essential role in cell cycle progression, and it associates with the DDB1-CUL4 E3 ligase complex.

Gene ID

9730

Gene Name (eCommerce)

DDB1 and CUL4 associated factor 1

Gene Name (Vector)

DDB1 and CUL4 associated factor 1

Gene Symbol

DCAF1

HGNC ID

HGNC:30911

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

4521

ORF Size (bp)

4521 bp

Protein Name (eCommerce)

Protein VPRBP

RefSeq ID

NM_014703

RefSeq Synonyms

NM_014703, NM_001171904, BC110371, BC022792,

Research Areas

Antigen Processing and Presentation,Cell Biology,Cell Cycle,Immunology,Kinase/Phosphatase,Transcription Factor/Regulator,Translational Control,Ubiquitination

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

VprBP (HIV-1 Vpr-binding protein) is also known as DCAF1 (Ddb1- and Cul4-associated factor 1). VprBP was initially identified as a protein that co-immunoprecipitated with the HIV protein, viral protein R; however the physiological relevance of this association remains unclear. It has recently been shown that VprBP plays an essential role in cell cycle progression, and it associates with the DDB1-CUL4 E3 ligase complex.

UniGene ID

Hs.716623

UniProt ID (eCommerce)

Q9Y4B6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.