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human UBA1 shRNA silencing AAV

Name 
AAV-h-UBA1-shRNA
Cat No 
shAAV-226960
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UBA1.

shAAV-226960
AAV-h-UBA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBA1 (ubiquitin like modifier activating enzyme 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A1S9; A1S9T; A1S9T and BN75 temperature sensitivity complementing; A1ST; AMCX1; CFAP124; GXP1; POC20; POC20 centriolar protein homolog; Protein A1S9; SMAX2; testicular secretory protein Li 63; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1X; Ubiquitin-activating enzyme E1; ubiquitin-like modifier-activating enzyme 1
Description (eCommerce)
Ubiquitin activating enzyme 1 (UBE1) is an E1 enzyme of the three-step ubiquitination pathway. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. UBE1 is suggested to be important for a variety of cellular processes and pathways, and its activity is regulated through phosphorylation.
Description (Vector)
UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Gene ID
7317
Gene Name (eCommerce)
ubiquitin like modifier activating enzyme 1
Gene Name (Vector)
ubiquitin like modifier activating enzyme 1
Gene Symbol
UBA1
HGNC ID
HGNC:12469
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3177
ORF Size (bp)
3177 bp
Protein Name (eCommerce)
Ubiquitin-like modifier-activating enzyme 1
RefSeq ID
NM_003334
RefSeq Synonyms
NM_153280, NM_003334, BC013041,
Research Areas
Antigen Processing and Presentation,Apoptosis,Complexome,Immunology,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,Ubiquitination
Research Areas (Faceted)
cell_biology,immunology,neurobiology
Species
human
Target Sentence
Ubiquitin activating enzyme 1 (UBE1) is an E1 enzyme of the three-step ubiquitination pathway. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes and the ligation of ubiquitin to the target protein by E3 enzymes. UBE1 is suggested to be important for a variety of cellular processes and pathways, and its activity is regulated through phosphorylation.
UniGene ID
Hs.533273
UniProt ID (eCommerce)
P22314

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.