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human UACA shRNA silencing AAV

Name 
AAV-h-UACA-shRNA
Cat No 
shAAV-226956
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human UACA.

shAAV-226956
AAV-h-UACA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
nuclear membrane binding protein; NUCLING; uveal autoantigen with coiled-coil domains and ankyrin repeats
Description (eCommerce)
UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves’ disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
Gene ID
55075
Gene Name (eCommerce)
uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene Name (Vector)
uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene Symbol
UACA
HGNC ID
HGNC:15947
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4251
ORF Size (bp)
4251 bp
Protein Name (eCommerce)
Uveal autoantigen with coiled-coil domains and ankyrin repeats
RefSeq ID
NM_018003
RefSeq Synonyms
NM_018003, NM_001008224, BC143267, BC143266, BC113409, BC113407,
Research Areas
Apoptosis,Cytoskeleton,Immunology,Mitochondrion
Research Areas (Faceted)
cell_biology,immunology
Species
human
Target Sentence
UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves’ disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
UniGene ID
Hs.108049
UniProt ID (eCommerce)
Q9BZF9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.