human TUBB3 shRNA silencing AAV

Name 
AAV-h-TUBB3-shRNA
Cat No 
shAAV-226831
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TUBB3.

shAAV-226831
AAV-h-TUBB3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TUBB3 (tubulin beta 3 class III). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
beta-4; CDCBM; CDCBM1; CFEOM3; CFEOM3A; class III beta-tubulin; FEOM3; TUBB4; tubulin beta-3 chain; tubulin beta-4 chain; tubulin beta-III; tubulin, beta 3
Description (eCommerce)
Beta III is a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta III tubulin is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. [taken from NCBI Entrez Gene (Gene ID: 10381)].
Description (Vector)
TUBB3 encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
Gene ID
10381
Gene Name (eCommerce)
tubulin beta 3 class III
Gene Name (Vector)
tubulin beta 3 class III
Gene Symbol
TUBB3
HGNC ID
HGNC:20772
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
Protein Name (eCommerce)
Tubulin beta-3 chain
RefSeq ID
NM_006086
RefSeq Synonyms
NM_006086, NM_001197181, BC003021, BC000748,
Research Areas
Axon Guidance,Cell Cycle,Cytoskeleton,GPCR Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Protein Folding,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Beta III is a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta III tubulin is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. [taken from NCBI Entrez Gene (Gene ID: 10381)].
UniGene ID
Hs.511743
UniProt ID (eCommerce)
Q13509

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.