human TRPM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TRPM2.
shAAV-226550
AAV-h-TRPM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TRPM2 (transient receptor potential cation channel subfamily M member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EREG1; estrogen-responsive element-associated gene 1 protein; KNP3; long transient receptor potential channel 2; LTRPC2; LTrpC-2; NUDT9H; NUDT9L1; transient receptor potential cation channel subfamily M member 2; transient receptor potential channel 7; transient receptor potential melastatin 2; TRPC7
Description (eCommerce)
TRPM2 (transient receptor potential cation channel subfamily M member 2) is a voltage-independent cation channel that mediates susceptibility to cell death in response to oxidative stress. TRPM2 is activated by adenosine diphosphoribose (ADP-ribose) and its activation is dependent on calcium and calmodulin levels. A splice variant of TRPM2, TRPM2-S, has been shown to interact with the full length form and suppress calcium influx and susceptibility to cell death.
Description (Vector)
TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Gene ID
7226
Gene Name (eCommerce)
transient receptor potential cation channel subfamily M member 2
Gene Name (Vector)
transient receptor potential cation channel subfamily M member 2
Gene Symbol
TRPM2
HGNC ID
HGNC:12339
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4662
ORF Size (bp)
4662 bp
Protein Name (eCommerce)
Transient receptor potential cation channel subfamily M member 2
RefSeq ID
NM_003307
RefSeq Synonyms
NM_003307, NM_001320352, NM_001320351, NM_001320350, BC112342,
Research Areas
Transport
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
TRPM2 (transient receptor potential cation channel subfamily M member 2) is a voltage-independent cation channel that mediates susceptibility to cell death in response to oxidative stress. TRPM2 is activated by adenosine diphosphoribose (ADP-ribose) and its activation is dependent on calcium and calmodulin levels. A splice variant of TRPM2, TRPM2-S, has been shown to interact with the full length form and suppress calcium influx and susceptibility to cell death.
UniGene ID
Hs.369759
UniProt ID (eCommerce)
O94759
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.