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human TRMT61A shRNA silencing AAV

Name 
AAV-h-TRMT61A-shRNA
Cat No 
shAAV-226523
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TRMT61A.

shAAV-226523
AAV-h-TRMT61A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRMT61A (tRNA methyltransferase 61A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C14orf172; GCD14; Gcd14p; hTRM61; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; TRM61; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A
Description (eCommerce)
TRMT61A is the catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96FX7].
Gene ID
115708
Gene Name (eCommerce)
tRNA methyltransferase 61A
Gene Name (Vector)
tRNA methyltransferase 61A
Gene Symbol
TRMT61A
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
870
ORF Size (bp)
870 bp
Protein Name (eCommerce)
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
RefSeq ID
NM_152307
RefSeq Synonyms
NM_152307, BC010167,
Research Areas
Methyltransferase,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
TRMT61A is the catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96FX7].
UniGene ID
Hs.525610
UniProt ID (eCommerce)
Q96FX7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.