human TPO shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TPO.
shAAV-226282
AAV-h-TPO-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TPO (thyroid peroxidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MSA; TDH2A; TPX
Description (Vector)
TPO encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
Gene ID
7173
Gene Name (Vector)
thyroid peroxidase
Gene Symbol
TPO
HGNC ID
HGNC:12015
ORF Size (aa)
2802
ORF Size (bp)
2802 bp
RefSeq ID
NM_000547
RefSeq Synonyms
NM_175722, NM_175721, NM_175719, NM_001206745, NM_001206744, NM_000547, BC095448, BC063107,
Species
human
UniGene ID
Hs.467554
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.