human TMED2 shRNA silencing AAV

Name 
AAV-h-TMED2-shRNA
Cat No 
shAAV-225674
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMED2.

shAAV-225674
AAV-h-TMED2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMED2 (transmembrane p24 trafficking protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
coated vesicle membrane protein; membrane protein p24A; p24; p24 family protein beta-1; P24A; p24b1; p24beta1; RNP24; transmembrane emp24 domain trafficking protein 2; transmembrane emp24 domain-containing protein 2
Description (eCommerce)
TMED2 is involved in vesicular protein trafficking. TMED2 mainly functions in the early secretory pathway but also in post-Golgi membranes. It is thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15363].
Gene ID
10959
Gene Name (eCommerce)
transmembrane p24 trafficking protein 2
Gene Name (Vector)
transmembrane p24 trafficking protein 2
Gene Symbol
TMED2
HGNC ID
HGNC:16996
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
606
ORF Size (bp)
606 bp
Protein Name (eCommerce)
Transmembrane emp24 domain-containing protein 2
RefSeq ID
NM_006815
RefSeq Synonyms
NM_006815, NM_001321445, BC025957,
Research Areas
Golgi Apparatus,Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,immunology
Species
human
Target Sentence
TMED2 is involved in vesicular protein trafficking. TMED2 mainly functions in the early secretory pathway but also in post-Golgi membranes. It is thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15363].
UniGene ID
Hs.592682
UniProt ID (eCommerce)
Q15363

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.