human TERF2IP shRNA silencing AAV

Name 
AAV-h-TERF2IP-shRNA
Cat No 
shAAV-225308
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TERF2IP.

shAAV-225308
AAV-h-TERF2IP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TERF2IP (TERF2 interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dopamine receptor-interacting protein 5; DRIP5; hRap1; RAP1; RAP1 homolog; repressor/activator protein 1 homolog; telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric RAP1 protein
Description (eCommerce)
Repressor/activator protein 1 homolog (RAP1) acts both as a regulator of telomere function and as a transcriptional regulator. RAP1 is involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, RAP1 is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NYB0].
Description (Vector)
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
Gene ID
54386
Gene Name (eCommerce)
TERF2 interacting protein
Gene Name (Vector)
TERF2 interacting protein
Gene Symbol
TERF2IP
HGNC ID
HGNC:19246
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
Protein Name (eCommerce)
Telomeric repeat-binding factor 2-interacting protein 1
RefSeq ID
NM_018975
RefSeq Synonyms
NM_018975, BC078171, BC022428, BC005841, BC004465,
Research Areas
Cell Cycle,DNA Damage/Repair,NF-kB Signaling,Signal Transduction,Telomeric Maintenance,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Repressor/activator protein 1 homolog (RAP1) acts both as a regulator of telomere function and as a transcriptional regulator. RAP1 is involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, RAP1 is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NYB0].
UniGene ID
Hs.301419
UniProt ID (eCommerce)
Q9NYB0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.