human TAX1BP1 shRNA silencing AAV

Name 
AAV-h-TAX1BP1-shRNA
Cat No 
shAAV-225050
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TAX1BP1.

shAAV-225050
AAV-h-TAX1BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TAX1BP1 (Tax1 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CALCOCO3; T6BP; Tax1 (human T-cell leukemia virus type I) binding protein 1; tax1-binding protein 1; TRAF6-binding protein; TXBP151
Description (eCommerce)
Tax1-binding protein 1 (TAX1BP1) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86VP1].
Description (Vector)
TAX1BP1 encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8887
Gene Name (eCommerce)
Tax1 binding protein 1
Gene Name (Vector)
Tax1 binding protein 1
Gene Symbol
TAX1BP1
HGNC ID
HGNC:11575
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2370
ORF Size (bp)
2370 bp
Protein Name (eCommerce)
Tax1-binding protein 1
RefSeq ID
NM_006024
RefSeq Synonyms
NM_006024, NM_001206902, NM_001206901, NM_001079864, BC050358,
Research Areas
Apoptosis,IFN Signaling,Immunology,Innate Immunity,Signal Transduction,TNF Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Tax1-binding protein 1 (TAX1BP1) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86VP1].
UniGene ID
Hs.34576
UniProt ID (eCommerce)
Q86VP1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.