human STX1A shRNA silencing AAV

Name
AAV-h-STX1A-shRNA

Cat No
shAAV-224660

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human STX1A.

shAAV-224660

AAV-h-STX1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STX1A (syntaxin 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HPC-1; P35-1; STX1; SYN1A

Description (Vector)

STX1A encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE (Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor) domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. STX1A product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

6804

Gene Name (Vector)

syntaxin 1A

Gene Symbol

STX1A

HGNC ID

HGNC:11433

ORF Size (aa)

756

RefSeq ID

NM_004603

RefSeq Synonyms

NM_004603, NM_001165903, BC064644, BC003011,

Species

human

UniGene ID

Hs.647024

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.