human STK39 shRNA silencing AAV

Name 
AAV-h-STK39-shRNA
Cat No 
shAAV-224601
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human STK39.

shAAV-224601
AAV-h-STK39-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STK39 (serine/threonine kinase 39). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DCHT; PASK; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine-protein kinase 39; small intestine SPAK-like kinase; SPAK; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase; Ste20-like protein kinase; ste-20-related kinase
Description (eCommerce)
STE20/SPS1-related proline-alanine rich protein kinase (SPAK) is a serine/threonine kinase that is thought to function in the cellular stress response pathway. This kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. Catalytically active SPAK specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress [taken from NCBI Entrez Gene (GeneID: 27347)].
Description (Vector)
STK39 encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Gene ID
27347
Gene Name (eCommerce)
serine/threonine kinase 39
Gene Name (Vector)
serine/threonine kinase 39
Gene Symbol
STK39
HGNC ID
HGNC:17717
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1638
ORF Size (bp)
1638 bp
Protein Name (eCommerce)
STE20/SPS1-related proline-alanine-rich protein kinase
RefSeq ID
NM_013233
RefSeq Synonyms
NM_013233, BC166614,
Research Areas
Cytoskeleton,Immunology,Kinase/Phosphatase,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
STE20/SPS1-related proline-alanine rich protein kinase (SPAK) is a serine/threonine kinase that is thought to function in the cellular stress response pathway. This kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. Catalytically active SPAK specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress [taken from NCBI Entrez Gene (GeneID: 27347)].
UniGene ID
Hs.276271
UniProt ID (eCommerce)
Q9UEW8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.