human STAT3 shRNA silencing AAV

acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; HIES; signal transducer and activator of transcription 3

STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein [taken from NCBI Entrez Gene (GeneID:6774)].

STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

6774

signal transducer and activator of transcription 3

signal transducer and activator of transcription 3

STAT3

HGNC:11364

9606.0

2310

2310 bp

Signal transducer and activator of transcription 3

NM_003150

NM_213662, NM_139276, NM_003150, BC014482, BC000627,

B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EPO Signaling,FGF Signaling,HGF Signaling,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Immuno-Oncology,Interleukin Signaling,JAK-STAT Signaling,Leptin Signaling,Leukemia,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,NGF Signaling,Notch Signaling,PDGF Signaling,Prolactin Signaling,Prostate Cancer,RAC1 Signaling,RNA Binding,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,TPO Signaling,Transcription Factor/Regulator,TSH Signaling,TSLP Signaling,Viral Carcinogenesis

cancer,cardiovascular,cell_biology,developmental_biology,genetics,immuno_oncology,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein [taken from NCBI Entrez Gene (GeneID:6774)].

Hs.463059

P40763