human SP1 shRNA silencing AAV

Name 
AAV-h-SP1-shRNA
Cat No 
shAAV-224035
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SP1.

shAAV-224035
AAV-h-SP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SP1 (Sp1 transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
specificity protein 1; transcription factor Sp1
Description (eCommerce)
Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.
Description (Vector)
SP1 is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
6667
Gene Name (eCommerce)
Sp1 transcription factor
Gene Name (Vector)
Sp1 transcription factor
Gene Symbol
SP1
HGNC ID
HGNC:11205
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2358
ORF Size (bp)
2358 bp
Protein Name (eCommerce)
Transcription factor Sp1
RefSeq ID
NM_138473
RefSeq Synonyms
NM_138473, NM_003109, NM_001251825, BC062539,
Research Areas
Breast Cancer,Cancer,EGFR Signaling,Estrogen Signaling,Gene Expression,Host-Virus Interactions,Huntington's Disease,Interleukin Signaling,Leptin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,Prostate Cancer,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.
UniGene ID
Hs.649191
UniProt ID (eCommerce)
P08047

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.