human SMARCB1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SMARCB1.
shAAV-223716
AAV-h-SMARCB1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAF47; BRG1-associated factor 47; CSS3; hSNF5; hSNFS; INI1; integrase interactor 1 protein; malignant rhabdoid tumor suppressor; MRD15; PPP1R144; protein phosphatase 1, regulatory subunit 144; RDT; RTPS1; Sfh1p; SNF5; SNF5 homolog; SNF5L1; Snr1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated protein; SWNTS1
Description (eCommerce)
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. SMARCA3 also known as HLTF (helicase-like transcription factor) has been shown to bind DNA promoter elements and stimulate transcription in cooperation with Sp1and Sp3 transcription factors.
Description (Vector)
SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
6598
Gene Name (eCommerce)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Gene Symbol
SMARCB1
HGNC ID
HGNC:11103
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1131
ORF Size (bp)
1131 bp
Protein Name (eCommerce)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
RefSeq ID
NM_003073
RefSeq Synonyms
NM_003073, NM_001317946, NM_001007468, BC143667, BC117114,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Host-Virus Interactions,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,TNF Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,infectious_disease,cell_biology,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation,cancer
Species
human
Target Sentence
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. SMARCA3 also known as HLTF (helicase-like transcription factor) has been shown to bind DNA promoter elements and stimulate transcription in cooperation with Sp1and Sp3 transcription factors.
UniGene ID
Hs.534350
UniProt ID (eCommerce)
Q12824
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.