human SLC7A11 shRNA silencing AAV

Name
AAV-h-SLC7A11-shRNA

Cat No
shAAV-223586

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SLC7A11.

shAAV-223586

AAV-h-SLC7A11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC7A11 (solute carrier family 7 member 11). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CCBR1; xCT

Description (Vector)

SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene ID

23657

Gene Name (Vector)

solute carrier family 7 member 11

Gene Symbol

SLC7A11

HGNC ID

HGNC:11059

ORF Size (aa)

1506

ORF Size (bp)

1506 bp

RefSeq ID

NM_014331

RefSeq Synonyms

NM_014331, BC012087,

Species

human

UniGene ID

Hs.390594

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.