human SLC7A11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SLC7A11.
shADV-223586
Ad-h-SLC7A11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SLC7A11 (solute carrier family 7 member 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CCBR1; xCT
Description (Vector)
SLC7A11 encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Gene ID
23657
Gene Name (Vector)
solute carrier family 7 member 11
Gene Symbol
SLC7A11
HGNC ID
HGNC:11059
ORF Size (aa)
1506
ORF Size (bp)
1506 bp
RefSeq ID
NM_014331
RefSeq Synonyms
NM_014331, BC012087,
Species
human
UniGene ID
Hs.390594
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.