human F13B Over-expression AAV
This is an AAV expressing Human F13B.
AAV-208220
AAV-h-F13B
Ready-to-use AAV expressing Human F13B (coagulation factor XIII B chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FXIIIB
Description (Vector)
F13B encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Gene ID
2165
Gene Name (Vector)
coagulation factor XIII B chain
Gene Symbol
F13B
HGNC ID
HGNC:3534
ORF Size (aa)
1983
ORF Size (bp)
1983 bp
RefSeq ID
NM_001994
RefSeq Synonyms
NM_001994, BC148333,
Species
human
UniGene ID
Hs.435782
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.