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human SLC2A4 shRNA silencing AAV

Name 
AAV-h-SLC2A4-shRNA
Cat No 
shAAV-223349
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SLC2A4.

shAAV-223349
AAV-h-SLC2A4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC2A4 (solute carrier family 2 member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
glucose transporter type 4, insulin-responsive; GLUT4; GLUT-4; insulin-responsive glucose transporter type 4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2, facilitated glucose transporter member 4
Description (eCommerce)
Glucose transporter type 4 (GLUT4) is a member of the solute carrier family 2 (facilitated glucose transporter) family and functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membran [taken from NCBI Entrez Gene (Gene ID: 6517)].
Description (Vector)
SLC2A4 is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
Gene ID
6517
Gene Name (eCommerce)
solute carrier family 2 member 4
Gene Name (Vector)
solute carrier family 2 member 4
Gene Symbol
SLC2A4
HGNC ID
HGNC:11009
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1248
ORF Size (bp)
1248 bp
Protein Name (eCommerce)
Solute carrier family 2, facilitated glucose transporter member 4
RefSeq ID
NM_001042
RefSeq Synonyms
NM_001042, BC126164, BC113592, BC069621, BC069615, BC034387,
Research Areas
Golgi Apparatus,Insulin Signaling,Leptin Signaling,Metabolism/Metabolic Process,PI3K/Akt Signaling,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism,signal_transduction,signal_transduction,cell_biology
Species
human
Target Sentence
Glucose transporter type 4 (GLUT4) is a member of the solute carrier family 2 (facilitated glucose transporter) family and functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membran [taken from NCBI Entrez Gene (Gene ID: 6517)].
UniGene ID
Hs.380691
UniProt ID (eCommerce)
P14672

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.