human SLC10A1 shRNA silencing AAV

Name
AAV-h-SLC10A1-shRNA

Cat No
shAAV-223067

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SLC10A1.

shAAV-223067

AAV-h-SLC10A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC10A1 (solute carrier family 10 member 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NTCP

Description (Vector)

SLC10A1 belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

Gene ID

6554

Gene Name (Vector)

solute carrier family 10 member 1

Gene Symbol

SLC10A1

HGNC ID

HGNC:10905

ORF Size (aa)

1050

RefSeq ID

NM_003049

RefSeq Synonyms

NM_003049, BC136355, BC126298, BC074724, BC069822, BC069799,

Species

human

UniGene ID

Hs.952

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.