human SERPINA1 shRNA silencing AAV

Name 
AAV-h-SERPINA1-shRNA
Cat No 
shAAV-222666
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SERPINA1.

shAAV-222666
AAV-h-SERPINA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SERPINA1 (serpin family A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A1A; A1AT; AAT; alpha-1 antitrypsin; alpha-1 protease inhibitor; alpha-1-antiproteinase; alpha-1-antitrypsin; alpha-1-antitrypsin null; alpha-1-antitrypsin short transcript variant 1C4; alpha-1-antitrypsin short transcript variant 1C5; alpha1AT; epididymis secretory sperm binding protein; nNIF; PI; PI1; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin A1; serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Description (eCommerce)
Alpha-1-Antitrypsin (A1AT) is a liver-derived protein found in the serum that functions to inhibit enzymes released by inflammatory cells. Deficiencies can lead to tissue damage in the lung or the liver in the event that secretion is inhibited via mutation.
Description (Vector)
SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Gene ID
5265
Gene Name (eCommerce)
serpin family A member 1
Gene Name (Vector)
serpin family A member 1
Gene Symbol
SERPINA1
HGNC ID
HGNC:8941
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
Protein Name (eCommerce)
Alpha-1-antitrypsin
RefSeq ID
NM_000295
RefSeq Synonyms
NM_001127707, NM_001127706, NM_001127705, NM_001127704, NM_001127703, NM_001127702, NM_001127701, NM_001127700, NM_001002236, NM_001002235, NM_000295, BC015642, BC011991,
Research Areas
Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Alpha-1-Antitrypsin (A1AT) is a liver-derived protein found in the serum that functions to inhibit enzymes released by inflammatory cells. Deficiencies can lead to tissue damage in the lung or the liver in the event that secretion is inhibited via mutation.
UniGene ID
Hs.525557
UniProt ID (eCommerce)
P01009

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.