human SATB2 shRNA silencing AAV

Name 
AAV-h-SATB2-shRNA
Cat No 
shAAV-222275
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SATB2.

shAAV-222275
AAV-h-SATB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SATB2 (SATB homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DNA-binding protein SATB2; GLSS; SATB family member 2; special AT-rich sequence-binding protein 2
Description (eCommerce)
The SATB2 (Special AT-rich Sequence-Binding Protein 2) gene has been identified as part of a chromosomal translocation involving 2q32-q33 that results in isolated cleft palate (CPO). SATB2 is an AT-rich DNA binding protein. In the rat, SATB2 expression is specific to the developing neocortex, and it is suggested to play a role in chromatin organization and gene expression in the brain.
Description (Vector)
SATB2 encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.
Gene ID
23314
Gene Name (eCommerce)
SATB homeobox 2
Gene Name (Vector)
SATB homeobox 2
Gene Symbol
SATB2
HGNC ID
HGNC:21637
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1848
ORF Size (bp)
1848 bp
Protein Name (eCommerce)
DNA-binding protein SATB2
RefSeq ID
NM_015265
RefSeq Synonyms
NM_015265, NM_001172517, NM_001172509, BC103500, BC103492, BC099723, BC098136,
Research Areas
Chromatin Remodeling,Neurobiology,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation,neurobiology,developmental_biology,genetics
Species
human
Target Sentence
The SATB2 (Special AT-rich Sequence-Binding Protein 2) gene has been identified as part of a chromosomal translocation involving 2q32-q33 that results in isolated cleft palate (CPO). SATB2 is an AT-rich DNA binding protein. In the rat, SATB2 expression is specific to the developing neocortex, and it is suggested to play a role in chromatin organization and gene expression in the brain.
UniGene ID
Hs.516617
UniProt ID (eCommerce)
Q9UPW6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.