human RPL7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RPL7.
shAAV-221735
AAV-h-RPL7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RPL7 (ribosomal protein L7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
60S ribosomal protein L7; humL7-1; L7; large ribosomal subunit protein uL30
Description (eCommerce)
RPL7 is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RPL7 is a member of the L30P family of ribosomal proteins and can bind both DNA and RNA in vitro. RPL7 is a cytoplasmic protein implicated to play a regulatory role in translation. It has also been identified as an auto-antigen in patients with autoimmune diseases such as lupus erythematosus.
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6129
Gene Name (eCommerce)
ribosomal protein L7
Gene Name (Vector)
ribosomal protein L7
Gene Symbol
RPL7
HGNC ID
HGNC:10363
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
747
Protein Name (eCommerce)
60S ribosomal protein L7
RefSeq ID
NM_000971
RefSeq Synonyms
NM_000971, BC087837, BC071895, BC071894, BC071671, BC009599, BC008850, BC006095,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,RNA Binding,RNA Processing,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
RPL7 is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RPL7 is a member of the L30P family of ribosomal proteins and can bind both DNA and RNA in vitro. RPL7 is a cytoplasmic protein implicated to play a regulatory role in translation. It has also been identified as an auto-antigen in patients with autoimmune diseases such as lupus erythematosus.
UniGene ID
Hs.571841
UniProt ID (eCommerce)
P18124
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.