human RPL14 shRNA silencing AAV

Name 
AAV-h-RPL14-shRNA
Cat No 
shAAV-221595
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPL14.

shAAV-221595
AAV-h-RPL14-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPL14 (ribosomal protein L14). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
60S ribosomal protein L14; CAG-ISL 7; CAG-ISL-7; CTG-B33; hRL14; L14; large ribosomal subunit protein eL14; RL14
Description (eCommerce)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL14 is a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm [taken from NCBI Entrez Gene (Gene ID: 9045)].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
9045
Gene Name (eCommerce)
ribosomal protein L14
Gene Name (Vector)
ribosomal protein L14
Gene Symbol
RPL14
HGNC ID
HGNC:10305
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
651
Protein Name (eCommerce)
60S ribosomal protein L14
RefSeq ID
NM_003973
RefSeq Synonyms
NM_003973, NM_001034996, BC071913, BC029036, BC019651, BC009294, BC005134, BC000606,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL14 is a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm [taken from NCBI Entrez Gene (Gene ID: 9045)].
UniGene ID
Hs.446522
UniProt ID (eCommerce)
P50914

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.