human RHOG shRNA silencing AAV

Name
AAV-h-RHOG-shRNA

Cat No
shAAV-221184

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RHOG.

shAAV-221184

AAV-h-RHOG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RHOG (ras homolog family member G). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARHG

Description (Vector)

RHOG encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.

Gene ID

391

Gene Name (Vector)

ras homolog family member G

Gene Symbol

RHOG

HGNC ID

HGNC:672

ORF Size (aa)

576

RefSeq ID

NM_001665

RefSeq Synonyms

NM_001665, BC104178, BC104177,

Species

human

UniGene ID

Hs.501728

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.